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At the tissue and organ levels, typical hallmarks of immunosenescence include thymic involution, chronic low-grade inflammation (“inflammaging”), and the pathological accumulation of senescent cells (SnCs) [1]

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the ALAS2 (zebrafish eALAS ) transcript contains an IRE in its 5′UTR and is highly expressed in erythroid cells, whereas the ALAS1 transcript is expressed in other tissues and lacks an IRE