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The fact, however, that OvSH exists as thiolate nearly throughout the pH scale, explains its wide pH range antioxidant potency compared to conventional thiols such as glutathione (latter is inherently a stronger reducing agent, but it exists mostly in the ‘inactive’ protonated form at neutral pH and below)

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These enzymes are able to act as a conduit for electrons from nascent polypeptides to the ER oxidases