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In aged Rhesus monkeys, Epitalon treatment stimulated melatonin production and restored youthful secretion patterns, while also normalizing cortisol rhythms in a time-of-day–dependent manner [59]

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It's attracted growing interest in research circles because of how directly it targets a specific enzymatic pathway - which makes it a useful tool for studying how NNMT activity influences downstream metabolic signalling at the cellular level