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Antihistamines like hydroxyzine and diphenhydramine are frequently employed as initial treatments for pruritus due to their safety and availability

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These antioxidant properties in the electron transport chain in the mitochondria enhance the efficiency of the electron transport, preventing the loss of uncontrolled electrons, help to recycle other antioxidants such as vitamin C or vitamin E, and directly act on free radicals or oxidants, reducing and neutralizing the compounds