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On the other hand, the Kcnj10 level, encoding Kir4.1 protein, did not change in our AAV2-hEDN1 model, unlike after ET-2 injection

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Thus, there is an apparent contradiction: on the one hand there is ample evidence for a role of ROS in various diseases, and antioxidant-rich food is generally associated with health, but antioxidant supplements do not prevent disease and are even associated with a poor health outcome