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[104] reported that P-15 alone is not capable of upregulating the proliferation and calcifying potential of human osteoblasts in vitro

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Translational data from a phase I/Ib clinical trial in patients with locally advanced laryngeal or oral cavity cancer treated with preoperative SBRT and durvalumab followed by surgical resection identified an increase in activated T cells with SBRT and ICB compared with those patients who did not receive the trial treatments (Darragh et al., 2022a, 2022b)