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In healthy mitochondria, SIRT3 interacts with ATP5O, while the low pH owing to the loss of membrane potential weakens the binding affinity between SIRT3 and ATP5O, leading to the redistribution of SIRT3 to other mitochondria substrates

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Because of two compounds in coffee: cafestol and kahweol, that appear to switch on a liver detox enzyme, at least in lab studies

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