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Thus in the “normal” physiological homeostatic range, Nrf2 is required to maintain the ROS/antioxidant balance

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Introduction Over the years, numerous epidemiological studies have highlighted a decreased incidence of cancer and improved survival in patients with higher dietary intakes of vitamin C or higher plasma levels of the vitamin ( Treatment of cancer, in contrast, is thought to require much higher doses of vitamin C than normal dietary intakes (Parrow et al., 2013)