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Keywords : 16S sequencing, interstitial cystitis, bladder pain syndrome, microbiome, urinary microbiome Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic disease that affects the bladder or urethra, disrupting urinary processes and causing unpleasant pelvic pain.[1] The major cause of IC/BPS remains unclear, and it is associated with unknown specific identifiable triggers