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MTHFR: HOMOZYGOUS MUTATION AND CORRELATED CARDIOVASCULAR RISK Methylenetetrahydrofolate reductase (MTHFR) is an enzyme involved in the transformation of 5-10 methylenetetrahydrofolate into 5-methyltetrahydrofolate which serves as a methyl donor for homocysteine methylation to methionine through the intervention of vitamin B12

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S16E, F), upregulated lipid ROS (Fig