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Injecting LPS or TNF-alpha systemically (intraperitoneal) in mice produced a rapid elevation in brain TNF-alpha levels that remained elevated for 10 months, while peripheral TNF-alpha levels fell to baseline by 9 hours.[199] The systemic LPS activated microglia in the substantia nigra and elevated proinflammatory cytokines during the entire period

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Occurrence and nature of O-alkyl and O-alk-I-enyl moieties of glycerol in lipids of Morris transplanted hepatomas and normal rat liver