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In contrast, males exhibited broader transcriptional disruption of excitatory and myelination-related pathways, in line with prior work showing that prenatal adversity and cannabinoids impair oligodendrocyte maturation, axonal integrity, and glutamatergic signaling within reward-related regions [73, 74, 75]

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sustained-release preparations formulations of medicines that limit their solubility so that they are delivered at a slow but steady rate into the blood supply