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A 2026 review noted overlap between HS pathogenesis and monogenic disorders affecting epithelial–innate immune interactions, Th17 differentiation, neutrophil function, and inflammasome regulation, including STAT3-associated hyper-IgE syndrome, STAT1 gain-of-function disease, chronic granulomatous disease, and selected autoinflammatory syndromes

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They are moderate to severe intensity, often debilitating, and can have a pulsatile quality

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