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These medications reduce gastric acid production, which is necessary for releasing dietary vitamin B12 from food proteins and for maintaining the stability of the B12-intrinsic factor complex

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F., et al., “SIRT1 Activation Rescues the Mislocalization of RNA‐Binding Proteins and Cognitive Defects Induced by Inherited Cobalamin Disorders,” Metabolism 101 (December 2019): 153992