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The measure methodology has several mechanisms to account for situations when admissions are outside the control of providers, such as exclusion criteria for very ill or complicated patients, identification of planned admissions, a 10-day buffer period following discharge, and a risk adjustment model that includes demographic, clinical, and social risk factors

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The endogenous-acetylcholine-induced VEGF expression in neurons and astrocytes [302], the VEGF signaling system is in the rescuing effect of acetylcholine on NMDA-induced long-lasting hippocampal cell damage [303]