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Similarly, preclinical studies in Brca1/2-deficient breast cancer mouse models showed that olaparib, a selective PARP inhibitor, enhanced the anti-tumor efficacy of platinum-based therapies, leading to profound tumor growth suppression [401,402]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 34.Zhang JH, Chen JH, Guo B, Fang Y, Xu ZY, Zhan L, et al