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Notably, benefits extend to non-diabetic HF patients, where metformin enhances antioxidant capacity and prevents increases in left ventricular mass (Kamel et al., 2024)

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30 Recently, an increase in oxidative protein and DNA damage was associated with the decrease in intracellular and plasma GSH/GSSG in children with autism, suggesting that the reduced antioxidant defense capacity in these children may have functional consequence in terms of overt oxidative damage