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In conclusion, RGSH intervention can down-regulate the renal ACSL4 mRNA expression level and up-regulate the GPX4 mRNA expression level in the development of AKI, and reduce the lipid oxide and iron ion levels, thereby reducing iron accumulation, alleviating cell damage and ameliorating intraoperative AKI by inhibiting ferroptosis

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This process involves the combination of two molecules or molecular fragments to form a higher-order structure via non-covalent interactions or covalent bonds, enabling the rapid construction of complex molecular architectures with diverse physiological properties 3,4