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Furthermore, their combination with phosphodiesterase-4 (PDE4) inhibitors (e.g., roflumilast) enhances anti-inflammatory efficacy, particularly in neutrophilic asthma phenotypes (169)

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Neutralizing antibodies, particularly anti-S antibodies, specifically bind to the receptor-binding domain (RBD) subunit of the Spike protein, blocking its interaction with the ACE2 receptor and thereby preventing cellular infection 7