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There are plenty of examples of a molecule that we thought should work, and maybe even worked in animal studies, but then failed to produce the effect in humans Or frankly was outright dangerous in humans For example, consider compounds that clear the preclinical testing bar and enter phase 1 trials, roughly 30-50% still fail to advance to phase 2 Often because these drugs do not behave in humans as anticipated 3 – Do we understand safety, dosing and pharmacokinetics