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may improve only after treating underlying inflammation or CKD -Soluble transferrin receptor (sTfR): Normal -CRP/ESR: Raised 🩸 Iron Deficiency Anemia (IDA): - Low serum iron - High TIBC - Low ferritin - Low transferrin saturation - Microcytic, hypochromic RBCs - Reticulocyte count: Low → rapid increase after iron supplementation (marrow responds promptly) - Soluble transferrin receptor (sTfR): Elevated - CRP/ESR: Usually normal 🔹 Key Investigational Points ✅ High ferritin + low TIBC → hallmark of ACD

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AOD9604 Phase II clinical trial results