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In relation to lipids, small-molecule inhibitors of acyl-CoA synthetase long-chain family member 4 (ACSL4) (for example, rosiglitazone) 106,220,221 and lysophosphatidylcholine acyltransferase 3 (LPCAT3) (for example, ( R )-HTS-3) 115 — enzymes that localize primarily to the ER or endomembrane system — can effectively inhibit ferroptosis by reducing the levels of polyunsaturated fatty acids in one or more cellular compartments
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