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Isolated from human plasma, then reproduced in the lab · 4 peer-reviewed sources cited on this page In 1973, Loren Pickart and Michael Thaler published a short paper describing a tripeptide they had isolated from human plasma that changed how liver cells behaved in culture: it extended the survival of normal liver cells and pushed neoplastic liver cells toward faster growth (Pickart and Thaler, Nature New Biology, 1973, PMID 4349963)

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In the low-dose cranial irradiation (18–24 Gy), GHD is often the only deficiency hormone in pituitary gland (Torino et al., 2013), low radiation doses lead to variable GHD levels in patients with leukemia or brain tumors (Littley et al., 1989