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An alteration in the phosphorylation pattern, such as an increase in tyrosine phosphorylation, which results from pathological conditions, such as inflammation or elevated ROS, can alter the protein–protein interactions of occludin with ZO-1, ZO-2, and ZO-3, and thereby alter the membrane integrity 75

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It has also been suggested that the transfer of gut microbes from ADHD patients to healthy mice resulted in altered flora structure (Tengeler et al., 2020)