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RUO designation means: ❌ Not reviewed or approved for human administration by the FDA ❌ No legal claims about safety, efficacy, or therapeutic intent ❌ Manufacturer avoids clinical liability Yet it does not inherently mean: Low purity Contamination Inferior synthesis Unsafe chemistry The real danger you correctly highlight is unverified sourcing: Non-registered facilities No GMP discipline No validated cleaning protocols No batch traceability No endotoxin controls No sterility assurance level (SAL) I believe: Regulatory status is being confused with chemical reality