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The first solid evidence for the existence of stem cells, and in particular hematopoietic stem cells, was reported from studies done in mice by Ernest McCulloch and James Till in 1963

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Interestingly, we found high hepatic expression of PGC-1β in mice that received high fat diet independent of drug treatment, whereas APAP per se halved the mRNA levels of PGC-1β in a chow diet background, thus implying a kind of protective mechanism exerted in normal conditions