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Why do some people lose substantial weight with GLP-1-based medications while others see more modest results? A Mayo Clinic study offers a potential answer by identifying a distinct biological subtype of obesity

Who it's most relevant for : People who feel like their metabolism has slowed significantly, those who struggle with energy alongside weight challenges, and anyone whose diet or health history suggests possible B12 insufficiency (common in people who eat little red meat, have digestive absorption issues, or take certain medications like metformin)

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Route of administration also affects observed half-life