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The reconstruction of particles from the first class reached 4.8 Å resolution and showed an asymmetric holo-complex (Supplementary Fig

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Furthermore, the ability to classify poorly differentiated tumor types using the miRNA expression profile in contrast to the mRNA profile, being small and stable, and the ability to be obtained from formalin fixed paraffin embedded samples, frozen samples, as well as blood, makes miRNA a novel and promising candidate as a prognostic marker and potential drug target (178, 179)