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Memantine is a low- to moderate-affinity uncompetitive NMDA receptor antagonist that is approved as a symptomatic treatment for Alzheimer’s disease dementia by the FDA, TPD, EMA, TGA, and Japan’s Pharmaceuticals and Medical Devices Agency (PMDA) [86–88]

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11 GSH depletion and the subsequent low stores of protein thiol result in both calcium release from intracellular stores and inhibition of calcium extrusion, producing a marked increase in cytosolic calcium concentration, which triggers cytotoxicity