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The following information is available as a result of research into the role of vitamin C in skin health, and Table 2 and Table 4 list a sample of key studies: Skin fibroblasts have an absolute dependence on vitamin C for the synthesis of collagen, and for the regulation of the collagen/elastin balance in the dermis

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Furthermore, there remains an incomplete consensus on the optimal preclinical models and safety endpoints for live microbes utilized outside the GI tract or in high-risk clinical environments (525)

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