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59 Unlike IGFs, insulin selectively inhibits the transcription of both genes IGFBP-1 60, 61 and IGFBP-2

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Ultimately, both GL and GA and their metabolites are primarily eliminated via bile and feces, with only a small fraction excreted in urine (Figure 2) ( 3 Core pharmacological mechanisms of glycyrrhizin in the liver GA exerts hepatoprotective effects through multiple pathways and targets, forming a synergistic network that includes anti-inflammatory, antioxidant, liver-protecting, and immunomodulatory actions (Xie et al., 2015) (Table 2