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4,868,114 discloses a method comprising stimulating the biosynthesis of glutathione in mammalian cells by contacting the cells with an effective amount of a compound of the formula (1): wherein R is a (CHOH) n CH 2 OH and wherein n is 1-5

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The study revealed that 4-HNE induces myocardial adiponectin (APN) resistance, characterized by increased systemic APN concentrations but diminished myocardial APN signaling, thereby impairing coronary angiogenesis