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The controllable Cas9 variant was further fused with deaminase APOBEC1, giving the resulting BaseBAC with the enzymatic activity of a cytosine base editor (CBE), which permits on-demand base editing on the GSDME gene, leading to the production of a truncated version of its N-terminal domain, which triggers pyroptosis

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Safe and appropriate dosing for off-label medications can only be determined by a primary care veterinarian

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