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Recent studies have shown that PGC-1α inhibits ferroptosis in models of cerebral ischemia, myocardial ischemia-reperfusion, and kidney injury [46,47,48]

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First identified in 1977 from cerebral venous blood of rabbits during electrically induced sleep by Swiss researchers Schoenenberger and Monnier, DSIP has since been studied for its role in sleep architecture regulation, stress response modulation, and neuroendocrine activity