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Luteolin-rich fraction from Perilla frutescens seed meal inhibits spike glycoprotein S1 of SARS-CoV-2-induced NLRP3 inflammasome lung cell inflammation via regulation of JAK1/STAT3 pathway: a potential anti-inflammatory compound against inflammation-induced long-COVID

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Studies in mouse model of MD (Mo-br mice) have shown that ES can transport Cu ions into mitochondria, elevate brain CCO levels, prevent detrimental neurodegenerative changes, and improve survival (Guthrie et al., 2020) (Table 2)