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However, recent research has shown that GM-CSF is a proinflammatory cytokine ( + T cells, innate lymphoid cells (ILCs), NK cells, γδ T cells, but CD4 + T lymphocytes were described as the main producers of this cytokine ( 3 Iron metabolism and encephalitogenic T lymphocytes in MS: A therapeutically promising duo Iron (Fe) is the most abundant chemical element on earth and it can exist in two main forms: ferrous iron (Fe 2+ ) or ferric iron (Fe 3+ )