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TGF-β signaling interferes with most of the therapeutic targets in CKD treatment including the RAA system and HIF pathway [126, 127, 128, 129]

Peptide hormone

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Examples include heme oxygenase-1 (HO-1), which is a key anti-inflammatory protein that catalyzes the degradation of heme into carbon monoxide (CO), iron ions, and biliverdin, thereby exerting antioxidant and anti-inflammatory effects (Sha et al., 2023)