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Correlation Between Erythrocyte Glutathione Levels and Severity of Melasma

- Indirect inactivation of tyrosinase via antioxidant effect which leads to quenching of free radicals and peroxides

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Redox-sensitive transcription factors like Nrf2, in turn, orchestrate antioxidant defense pathways in a circadian manner, highlighting a bidirectional relationship between circadian regulation and redox homeostasis [6]