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Tracking motor neuron loss in a set of six muscles in amyotrophic lateral sclerosis using the Motor Unit Number Index (MUNIX): a 15-month longitudinal multicentre trial

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Thus, peri-fibrocartilageneous bone and entheses represent a primary site and tissue target where innate and adaptive reactions occur initially as a repair process, but in later phases can result in remodeling effects including bone oedema, osteitis, new bone formation, and in some cases spine fusion in those genetically predisposed (Figure 3)