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(2023) demonstrated that ORI significantly increases the proportion of Cluster of Differentiation 4 positive (CD4 + ), Cluster of Differentiation 25 positive (CD25 + ), Forkhead box P3 positive (Foxp3 + ) Treg cells while suppressing the expression of pro-inflammatory cytokines TNF-α and Interleukin-1 beta (IL-1β)

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