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Regarding the metabolic switch role of frataxin, its depletion would provoke the enhancement in the reduction of ISC formation at the ISCU machinery level and at the end, subjecting the cell to increased iron accumulation and ROS production (Yoon and Cowan, 2004)

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They also discovered that there is a negative correlation between N -acetylaspartate levels in dorsolateral prefrontal cortex and negative symptoms in schizophrenia (Smucny et al., 2022)