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Its primary function is G-actin sequestration — TB4 binds monomeric actin with nanomolar affinity, regulates the polymerizable actin pool, and indirectly governs cytoskeletal dynamics during cell migration, wound healing and inflammatory response

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This metabolic bottleneck is why liver function tests (AST, ALT, bilirubin, albumin) must be monitored before and during any weight loss therapy