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The recognition that contraction-induced free radicals can influence muscle function and fatigue can be attributed to several investigators including Gerald Supinski, Michael Reid, Jack Barclay, and their colleagues as much of this work was published in the early 1990s (34, 321, 322, 325, 361)

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Recent studies indicate that oxidative stress primarily induces necrosis, but not apoptosis, and the underlying mechanisms remain unclear