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MRP2 is shown to be deficient in the hereditary condition known as Dubin-Johnson syndrome, which causes chronic conjugated hyperbilirubinemia and hepatocytes are not able to excrete conjugated organic anions into bile (Keppler and Konig, 1997)

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Copper tripeptide has been shown to increase messenger RNA production for collagen, elastin, proteoglycans, and glycosaminoglycans in fibroblasts