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Aβ amyloid beta peptide AICD amyloid intracellular domain AD Alzheimer’s disease Al aluminum AGE advanced glycation end products ApoE apolipoprotein E APP amyloid precursor protein As arsenic α -syn alpha-synuclein BACE1 beta-site APP cleaving enzyme 1 Cd cadmium CSF cerebrospinal fluid EOAD early-onset Alzheimer’ disease Hg mercury HR hazard ratio IDE insulin-like degrading enzyme LB Lewy bodies LOAD late-onset Alzheimer’ disease LRP1 low density lipoprotein receptor-related protein 1 Me-Hg methyl mercury Mn manganese MTs microtubules NEP neprilysin NFTs neurofibrillary tangles NPs nanoparticles OP organophosphates OCl organochlorines PHFs paired helical filaments Pb lead PD Parkinson’s disease PQ paraquat PS presenilin ROS reactive oxygen species RR relative risk sAPPβ soluble APP beta SNpc substantia nigra pars compacta SNpr substantia nigra pars reticulate Tau tau protein P-Tau phosphorylated Tau TCE trichloroethylene Zn zinc

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