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Visualisation was performed using PyMol software ( Expression and purification of recombinant proteins Protein expression and purification were performed as previously described [23, 67] with the following modifications

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Through such metabolic crosstalk, metformin seems to counteract the pro-inflammatory milieu induced by senescent subsets of immune cells in MS (177), RA (178), and SLE (179), as reported in Table 1

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