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Selenium, an essential trace nutrient, contributes to GPX4 stability and enzymatic activity by cooperating with transcription factors TFAP2c and Sp1, exerting protective effects against ferroptosis in neurons (96)

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In particular, both superoxide dismutase (SOD) and catalase (CAT) play crucial antioxidant roles in the epidermis, showing a gradient of activity that decreases toward the skin surface