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In the United States, 7.8% of the population have diabetes, 35.4% have impaired fasting glucose (IFG) levels, 15.4% have impaired glucose tolerance (IGT), and 40.1% have pre-diabetes (IFG, IGT, or both) (57), while in China 9.7% and 15.5% of people are positive for diabetes and pre-diabetes, respectively (58)

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Additionally, in a mouse model involving the adoptive transfer of microbiota-specific T cells, butyrate-stimulated IL-10 secretion by Th1 and Th17 cells reduced colitis severity ( In vitro , butyrate and propionate also suppress LPS-induced maturation of human monocyte-derived dendritic cells, leading to reduced IL-12 secretion and diminished CD8 + T cell activation (Nastasi et al., 2017)