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A meta-analysis found a trend toward decreased ototoxicity (ear toxicity or hearing impairment) in patients receiving amifostine infusion prior to cisplatin chemotherapy (Duval 2012)

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Thus, the mutant Asn240Lys demonstrates that the amino acid at the 1 st activity controller position can influence the tyrosinase activity but is not able to completely shut down monophenolase activity

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