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HK-2 cells were exposed to control or HG, with or without Cur-NCs (1.87, 3.75, 7.5 μg/mL), Ferrostatin-1 (1 μM, S81461, Shanghai yuanye Bio-Technology Co., Ltd., China), Erastin (35 μM, S80804, Shanghai yuanye Bio-Technology Co., Ltd., China) treatment alone or in combination for the specified time (0 h, 12 h, 24 h, or 48 h)

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In certain cases, it may relate only to mild and reversible dysfunction